Syntheses, Characterizations and Biological Screening of Titanium (iv) Complexes Derived from Antibiotic Drug(s)
نویسندگان
چکیده
Objective: To synthesis a series of novel titanium (IV) complexes with corresponding antibiotic drugs. Methods: A series of novel titanium (IV) complexes have been synthesized by reacting titanium tetrachloride with corresponding antibiotic drug (L) i.e. (L = A1 (tetracycline hydrochloride); B1 (Streptomycin); C1 (Cefixime); D1 (Ampicillin); E1 (Amoxicillin) in fixed 1:2 molar ratios using methanol as a solvent. All the synthesized complexes were characterized by microanalysis (titanium and chlorine were estimated by gravimetrical and Volhard’s method respectively) and spectroscopic methods (FT-IR, UV-Visible, 1H-NMR, Raman, SEM and Mass spectrometry). These complexes were screened for their antibacterial activity against ten pathogenic bacterial strains. Results: Zone of inhibition diameter and MIC data indicated that [Ti(E1)2Cl2] was highly effective against all the bacterial strains than parent ligand. Conclusion: From the spectral data an octahedral geometry was tentatively proposed for all the new titanium (IV) complexes. All the complexes exhibited promising antibacterial activity.
منابع مشابه
Syntheses and Biological screening of Schiff base complexes of Titanium(IV)
The novel titanium(IV) complexes of composition [TiCl2(SB)2] have been synthesized by reacting TiCl4 and Schiff bases (SBs) where (SBs = A1( tetracycline hydrochloride schiffs base) ;B1(Streptomycin schiffs base ) ;C1( Ceffixime schiffs base) ;D1( ampicillin schiffs base) in fixed molar ratio 1:2. Titanium and chlorine estimation were estimated by gravimetrical and Volhard method respectively. ...
متن کاملCatalytic enantioselective Strecker reactions and analogous syntheses.
3.1. Overview 2807 3.2. Chiral Aluminum(III) Complexes as a Catalyst 2808 3.2.1. Aluminum(III)-Salen-Based Catalysts 2808 3.2.2. Aluminum(III)-Binaphthol-Based Catalysts 2810 3.3. Chiral Titanium(IV) Complexes as a Catalyst 2814 3.3.1. Titanium(IV)-Peptide-Based Catalysts 2814 3.3.2. Titanium(IV)-Diol-Based Catalysts 2817 3.4. Chiral Zirconium(IV) Complexes as a Catalyst 2818 3.4.1. The Catalyt...
متن کاملSynthesis, Spectral, Biological and Theoretical Investigation of Some New Sn (IV) Complexes with Schiff Base Ligands Containing NNOS Coordination Sphere
New tin (IV) complexes of empirical formula, [Cl2 Me2 Sn(H2 L)1-3], where ((H2 L)1-3: Methyl-2- {[1-methyl-2-(2-hydroxy-3-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentenedithiocarboxylate [H2cd3OMesalMeen], Methyl-2-{[1-methyl-2-(2-hydroxy-4-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentenedithiocar-boxylate, [H2 cd4OMesalMeen], Methyl-2-{[1-methyl-2-(2-hydroxy-5-methoxyphe...
متن کاملSTEREOSELECTIVE SYNTHESES OF (+)- ISORETRONECANOL AND (+)-5-epi-TASHIROMINE VIA ADDITION OF CHIRAL TITANIUM (IV) ENOLATES TO CYCLIC N-ACYLIMINIUM IONS
The stereoselective addition of the titanium (IV) enolates derived from (S)-4-isopropyl-N-4-chlorobutyryl-1,3-thiazolidine-2-thione (8) and from (S)-4-isopropyl-N-4-chloropentanoyl-1,3-thiazolidine-2-thione (9) to N-Boc-2-methoxypyrrolidine (5b) afforded the addition products (+)-10 and (+)-11 in 84% yield in both cases, as 8.6:1 and 10:1 diastereoisomeric mixtures, respectively. A threestep se...
متن کامل